The story revolves around Dr. Meredith Grey (Ellen Pompeo), who began the show as a surgical intern at the fictional Seattle Grace Hospital in Seattle, Washington. She and the other former interns became residents at the end of Season 3. The show features an ensemble cast, though Meredith is featured as the central character, providing voice-over narration at the beginning and end of most episodes. The title of the show is an allusion to the anatomy textbook Gray’s Anatomy, and play on the central character’s (Meredith Grey’s) name.

Every episode title comes from the title of a song.

• 1. A Hard Day's Night 27/3/2005
• 2. The First Cut Is The Deepest 3/4/2005
• 3. Winning A Battle, Losing The War 9/4/2005
• 4. No Man's Land 17/4/2005
• 5. Shake Your Groove Thing 24/4/2005
• 6. If Tomorrow Never Comes 1/5/2005
• 7. The Self Destruct Button 8/5/2005
• 8. Save Me 15/5/2005
• 9. Who's Zoomin' Who? 22/5/2005

• 1. Raindrops Keep Falling On My Head 25/9/2005
• 2. Enough Is Enough (No More Tears) 2/10/2005
• 3. Make Me Lose Control 9/10/2005
• 4. Deny, Deny, Deny 16/10/2005
• 5. Bring The Pain 23/10/2005
• 6. Into You Like A Train 30/10/2005
• 7. Something To Talk About 6/11/2005
• 8. Let It Be 13/11/2005
• 9. Thanks For The Memories 20/11/2005
• 10. Much Too Much 27/11/2005
• 11. Owner Of A Lonely Heart 4/12/2005
• 12. Grandma Got Run Over By A Reindeer 11/12/2005
• 13. Begin The Begin 15/1/2006
• 14. Tell Me Sweet Little Lies 22/1/2006
• 15. Break On Through 29/1/2006
• 16. It's The End Of The World (1) 5/2/2006
• 17. (As We Know It) (2) 12/2/2006
• 18. Yesterday 19/2/2006
• 19. What Have I Done To Deserve This? 26/2/2006
• 20. Band Aid Covers The Bullet Hole 12/3/2006
• 21. Superstition 19/3/2006
• 22. Name Of The Game 2/4/2006
• 23. Blues For Sister Someone 30/4/2006
• 24. Damage Case 7/5/2006
• 25. 17 Seconds 14/5/2006
• 26. Deterioration Of The Fight Or Flight Response 15/5/2006
• 27. Losing My Religion 15/5/2006

• 1. Time Has Come Today 21/9/2006
• 2. I Am A Tree 28/9/2006
• 3. Sometimes A Fantasy 5/10/2006
• 4. What I Am 12/10/2006
• 5. Oh, The Guilt 19/10/2006
• 6. Let The Angels Commit 2/11/2006
• 7. Where The Boys Are 9/11/2006
• 8. Staring At The Sun 16/11/2006
• 9. From A Whisper To A Scream 23/11/2006
• 10. Don't Stand So Close To Me 30/11/2006
• 11. Six Days (1) 11/1/2007
• 12. Six Days (2) 18/1/2007
• 13. Great Expectations 25/1/2007
• 14. Wishin' And Hopin' 1/2/2007
• 15. Walk On Water (1) 8/2/2007
• 16. Drowning On Dry Land (2) 15/2/2007
• 17. Some Kind Of Miracle (3) 22/2/2007
• 18. Scars And Souvenirs 15/3/2007
• 19. My Favorite Mistake 22/3/2007
• 20. Time After Time 19/4/2007
• 21. Desire 26/4/2007
• 22. The Other Side Of This Life (1) 3/5/2007
• 23. The Other Side Of This Life (2) 3/5/2007
• 24. Testing 1-2-3 10/5/2007
• 25. Didn't We Almost Have It All 17/5/2007

• 1. A Change Is Gonna Come 27/9/2007
• 2. Love/Addiction 4/10/2007
• 3. Let The Truth Sting 11/10/2007
• 4. The Heart Of The Matter 18/10/2007
• 5. Haunt You Every Day 25/10/2007
• 6. Kung Fu Fighting 1/11/2007
• 7. Physical Attraction... Chemical Reaction 8/11/2007
• 8. Forever Young 15/11/2007
• 9. Crash Into Me (Part 1) 22/11/2007
• 10. Crash Into Me (Part 2) 6/12/2007
• 11. Lay Your Hands On Me 10/1/2008
• 12. Where The Wild Things Are 24/4/2008
• 13. Piece Of My Heart 1/5/2008
• 14. The Becoming 8/5/2008
• 15. Losing My Mind 15/5/2008
• 16. Freedom 1 & 2 22/5/2008
• 16. Episode 16 N/A